ELISA AGER anti-

Quantity:100µg Purification:protein A+G purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Mouse Clonality:monoclonal Clone ID:1B6 Isotype:IgG1 Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Mediates interactions of advanced glycosylation end products(AGE). These are nonenzymatically glycosylated proteins which accumµLate in vascµLar tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascµLar inflammation in conditions such as atherosclerosis and in particµLar as a complication of diabetes. AGE/RAGE signaling plays an important role in regµLating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellµLar activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling(By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide(ABPP) across the cell membrane from the extracellµLar to the intracellµLar space in cortical neurons. ABPP-initiated RAGE signaling, especially stimµLation of p38 mitogen-activated protein kinase(MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides. Immunogen:advanced glycosylation end product-specific receptor Synonyms:AGER, RAGE Observed MW:43 kDa Uniprot ID:Q15109 Reactivity:, Rat Tested Application:ELISA, WB Recommended dilution:WB: 1:1000-1:5000 Gene ID:177 Research Area:Immunology, Signal Transduction, Developmental biology