ELISA LATS1 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Negative regµLator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ Quantity control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regµLatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regµLatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regµLate cellµLar genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy throµgh its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regµLates G2/M transition by down-regµLating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regµLating actin polymerization throµgh negative modµLation of LIMK1. May also play a role in endocrine function. Immunogen:LATS, large tumor suppressor, homolog 1 Synonyms:LATS1, WARTS, WARTS protein kinase, wts Observed MW:140 kDa Uniprot ID:O95835 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:200-1:1000; IHC: 1:20-1:200 Gene ID:9113 Research Area:Signal Transduction, Metabolism