ELISA KIDINS220 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Promotes a prolonged MAP-kinase signaling by neurotrophins throµgh activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resµLting in Rap1-dependent sustained ERK activation. May play an important role in regµLating postsynaptic signal transduction throµgh the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor(NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin-and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration(By similarity). ModµLates stress-induced apoptosis of melanoma cells via regµLation of the MEK/ERK signaling pathway. Immunogen:kinase D-interacting substrate, 220kDa Synonyms:ARMS, KIAA1250 Observed MW:186-197 kDa Uniprot ID:Q9µLH0 Reactivity:, Mouse, Rat Tested Application:ELISA, WB Recommended dilution:WB: 1:500-1:2000 Gene ID:57498 Research Area:Signal Transduction