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ELISA IRAK1 anti-

https://www.vbrc.org/web/image/product.template/62608/image_1920?unique=e4af219
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Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor(TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins(PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs(CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regµLatory factor 7(IRF7) to induce its activation and translocation to the nucleus, resµLting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. Immunogen:interleukin-1 receptor-associated kinase 1 Synonyms:IRAK, IRAK 1, IRAK1, pelle Observed MW:70 kDa Uniprot ID:P51617 Reactivity:, Mouse, Rat Tested Application:ELISA, FC, IF, IHC, IP, WB Recommended dilution:WB: 1:500-1:3000; IP: 1:500-1:1000; IHC: 1:50-1:500; IF: 1:50-1:500 Gene ID:3654 Research Area:Immunology, Signal Transduction, Metabolism, Developmental biology

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