ELISA IPO13 anti-
Quantity:100µg
Purification:Immunogen affinity purified
Form:liquid
Purity:?95% as determined by SDS-PAGE
Host:Rabbit
Clonality:polyclonal
Clone ID:
Isotype:IgG
Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background:Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates. Is thoµght to mediate docking of the importin/substrate complex to the nuclear pore complex(NPC) throµgh binding to nucleoporin and the complex is subsequently translocated throµgh the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thoµght to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus(By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.
Immunogen:importin 13
Synonyms:KIAA0724, RANBP13
Observed MW:97kd
Uniprot ID:O94829
Reactivity:, Mouse, Rat
Tested Application:ELISA, WB, IHC, IF
Recommended dilution:WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Gene ID:9670
Research Area:Signal Transduction