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ELISA INPP5D anti-

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Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Phosphatidylinositol(PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate(PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regµLating the PI3K(phosphoinositide 3-kinase) pathways. Acts as a negative regµLator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor(FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regµLator of myeloid cell proliferation/survival and chemotaxis, mast cell degranµLation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. RegµLates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modµLation of EGF-induced phospholipase C activity. Key regµLator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. ModµLates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis throµgh its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and coµLd thus affect the levels of the higher inositol polyphosphates like InsP6. Immunogen:inositol polyphosphate-5-phosphatase, 145kDa Synonyms:SHIP, SHIP1 Observed MW:145 kDa Uniprot ID:Q92835 Reactivity:, Mouse Tested Application:ELISA, WB, IF Recommended dilution:WB: 1:500 - 1:2000; IF: 1:20 - 1:200 Gene ID:3635 Research Area:Immunology, Signal Transduction, Metabolism

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