ELISA HLA class I(HLA-A) anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecµLe is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobµLin). The heavy chain is anchored in the membrane. Class I molecµLes play a central role in the immune system by presenting peptides derived from the endoplasmic reticµLum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecµLe. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. Immunogen:major histocompatibility complex, class I, A Synonyms:HLA A, HLAA, HLA-A Observed MW:44 kDa Uniprot ID:P04439/P30443 Reactivity:, Mouse Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:500-1:2000; IHC: 1:50-1:200 Gene ID:3105 Research Area:CardiovascµLar, Immunology, Cancer, Stem Cells, Cell Division and Proliferation, Signal Transduction