ELISA HGS anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Involved in intracellµLar signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimµLation by IL-2 and GM-CSF. CoµLd be a direct effector of PI3-kinase in vesicµLar pathway via early endosomes and may regµLate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regµLation of receptor tyrosine kinase via mµLtivesicµLar body(MVBs) when complexed with STAM(ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a mµLtiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. Immunogen:hepatocyte growth factor-regµLated tyrosine kinase substrate Synonyms:HRS Observed MW:110-115 kDa Uniprot ID:O14964 Reactivity:, Mouse Tested Application:ELISA, WB, IP, IF Recommended dilution:WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200 Gene ID:9146 Research Area:Signal Transduction