ELISA ALK,CD246 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a 220 kDa transmembrane glycoprotein that is primarily expressed in the developing nervous system. ALK contains one LDL Receptor (LDLR) class A domain, two meprin/A5-protein/PTPmu (MAM) domains, and a cytoplasmic kinase domain. Chromosomal translocation involving ALK and the nucleolar NPM protein resµLt in a cytoplasmic fusion protein that exists as a dimer. The kinase domain in NPM-ALK is constitutively active and participates in cellµLar transformation. ALK translocations are found in a variety of tumors. Within the extracellµLar domain, and mouse ALK share 88% amino acid sequence identity. Immunogen:anaplastic lymphoma receptor tyrosine kinase Synonyms:ALK, ALK tyrosine kinase receptor, ALK,CD246, Anaplastic lymphoma kinase, CD246, TFG/ALK Observed MW:140-220 kDa Uniprot ID:Q9UM73 Reactivity:, Mouse, Rat Tested Application:ELISA, IHC, WB Recommended dilution:WB: 1:500-1:2000; IHC: 1:20-1:200 Gene ID:238 Research Area:Signal Transduction, Metabolism, Immunology, Cancer, Developmental biology, Neuroscience