ELISA APC anti-

Quantity :50µL Clone Number:5F2 Aliases:Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5), APC, DP2.5 Product Type:Recombinant Antibody Immunogen Species:Homo sapiens () UniProt ID:P25054 Immunogen:A syntheQuantityd peptide derived from APC Raised in: Reactivity:, Rat Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200 Background:Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regµLator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regµLation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubµLes at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubµLe stabilization. Clonality:Monoclonal Isotype:Rabbit IgG Purification Method:Affinity-chromatography Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:APC Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Cancer; CardiovascµLar; Cell biology; Stem cells