ELISA ARG2 anti-

Quantity :50µL Clone Number:9A4 Aliases:Arginase-2, mitochondrial (EC 3.5.3.1) (Arginase II) (Kidney-type arginase) (Non-hepatic arginase) (Type II arginase), ARG2 Product Type:Recombinant Antibody Immunogen Species:Homo sapiens () UniProt ID:P78540 Immunogen:A syntheQuantityd peptide derived from ARG2 Raised in: Reactivity: Tested Applications:ELISA, IHC, IF, FC; Recommended dilution: IHC:1:50-1:200, IF:1:50-1:200, FC:1:50-1:200 Background:May play a role in the regµLation of extra-urea cycle arginine metabolism and also in down-regµLation of nitric oxide synthesis. Extrahepatic arginase functions to regµLate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regµLator of innate and adaptive immune responses. Seems to be involved in negative regµLation of the survival capacity of activated CD4(+) and CD8(+) T cells (PubMed:27745970). May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (By similarity). In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation (PubMed:28614294). RegµLates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082). Involved in vascµLar smooth muscle cell senescence and apoptosis independently of its enzymatic activity (PubMed:23832324). Since NOS is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase-2 plays a role in both male and female sexual arousal (PubMed:12859189). {ECO:0000250|UniProtKB:O08691, ECO:0000269|PubMed:12859189, ECO:0000269|PubMed:22928666, ECO:0000269|PubMed:23832324, ECO:0000269|PubMed:25484082, ECO:0000269|PubMed:27214549, ECO:0000269|PubMed:27745970}. Clonality:Monoclonal Isotype:Rabbit IgG Purification Method:Affinity-chromatography Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ARG2 Research Areas:Metabolism; Signal transduction