ELISA HDAC5 (Ab-498) anti-

Quantity :100µL Clone Number: Aliases:Antigen NY CO 9 antibody; Antigen NY-CO-9 antibody; HD5 antibody; HDAC 5 antibody; HDAC5 antibody; HDAC5_ antibody; Histone deacetylase 5 antibody; NY CO 9 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9UQL6 Immunogen:Peptide sequence around aa.496~500 (T-Q-S-S-P) derived from HDAC5/7. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; WB:1:500-1:1000, IHC:1:50-1:200 Background: Histones play a critical role in transcriptional regµLation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC5 belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form mµLticomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resµLting in repression of MEF2-dependent genes. This gene is thoµght to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. Doppler H, et al. (2005) J Biol Chem. 280(15):15013-15019. McKinsey TA, et al. (2000) Nature. 408(6808): 106-111. Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:HDAC5 Research Areas:Epigenetics and Nuclear Signaling;CardiovascµLar;Stem cells