ELISA AXIN2 anti-

Quantity :50µL Clone Number: Aliases:Axil antibody; Axin like protein antibody; Axin-2 antibody; Axin-like protein antibody; Axin2 antibody; AXIN2_ antibody; Axis inhibition protein 2 antibody; Conductin antibody; DKFZp781B0869 antibody; MGC10366 antibody; MGC126582 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9Y2T1 Immunogen:Fusion protein of AXIN2 Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 Background:The Axin-related protein, Axin2, presumably plays an important role in the regµLation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a mµLtiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregµLation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:AXIN2 Research Areas:Epigenetics and Nuclear Signaling?Neuroscience?Cancer;Cell biology;Stem cells