ELISA LOXL2 Antibody, FITC

Quantity :50µg Clone Number: Aliases:LOR 2 antibody; LOR2 antibody; LOX L2 antibody; LOXL 2 antibody; LOXL2 antibody; LOXL2_ antibody; Lysyl oxidase homolog 2 antibody; Lysyl oxidase like 2 antibody; Lysyl oxidase like protein 2 antibody; Lysyl oxidase related 2 antibody; Lysyl oxidase related protein 2 antibody; Lysyl oxidase related protein WS9 14 antibody; Lysyl oxidase-like protein 2 antibody; Lysyl oxidase-related protein 2 antibody; Lysyl oxidase-related protein WS9-14 antibody; WS9 14 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9Y4K0 Immunogen:Recombinant Lysyl oxidase homolog 2 protein (27-121AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellµLar matrix, promotes cross-linking of extracellµLar matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regµLator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated \'Lys-4\' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, sµggesting that it may play a role in tumor progression. Acts as a regµLator of chondrocyte differentiation, probably by regµLating expression of factors that control chondrocyte differentiation. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:LOXL2 Research Areas:Cancer; Signal transduction