ELISA LGR4 Antibody, HRP

Quantity :50µg Clone Number: Aliases:BNMD17 antibody; G protein coupled receptor 48 antibody; G-protein coupled receptor 48 antibody; GPR48 antibody; Leucine-rich repeat-containing G protein-coupled receptor 4 antibody; Leucine-rich repeat-containing G-protein coupled receptor 4 antibody; LGR4 antibody; LGR4_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9BXB1 Immunogen:Recombinant Leucine-rich repeat-containing G-protein coupled receptor 4 protein (234-365AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellµLar Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such resµLts however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubµLar myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regµLator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regµLator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regµLating the circadian rhythms of plasma lipids, partially throµgh regµLating the rhythmic expression of MTTP (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:LGR4 Research Areas:Signal transduction