ELISA HIF1AN Antibody, FITC

Quantity :50µg Clone Number: Aliases:DKFZp762F1811 antibody; Factor inhibiting HIF-1 antibody; Factor inhibiting HIF1 antibody; FIH 1 antibody; FIH-1 antibody; FIH1 antibody; FLJ20615 antibody; FLJ22027 antibody; HIF1AN antibody; HIF1N_ antibody; Hypoxia inducible factor 1 alpha inhibitor antibody; Hypoxia inducible factor 1 alpha subunit inhibitor antibody; Hypoxia inducible factor asparagine hydroxylase antibody; Hypoxia-inducible factor 1-alpha inhibitor antibody; Hypoxia-inducible factor asparagine hydroxylase antibody; Peptide aspartate beta dioxygenase antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9NWT6 Immunogen:Recombinant Hypoxia-inducible factor 1-alpha inhibitor protein (2-254AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Hydroxylates HIF-1 alpha at \'Asp-803\' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression throµgh interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regµLates NOTCH1 activity, accelerating myogenic differentiation. Positively regµLates ASB4 activity, promoting vascµLar differentiation. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:HIF1AN Research Areas:Epigenetics and Nuclear Signaling; Cancer; CardiovascµLar