ELISA HMGB2 Antibody, HRP
Quantity :50µg
Clone Number:
Aliases:C80539 antibody; High mobility group (nonhistone chromosomal) protein 2 antibody; High mobility group box 2 antibody; High mobility group protein 2 antibody; High mobility group protein B2 antibody; HMG 2 antibody; HMG B2 antibody; HMG-2 antibody; HMG2 antibody; HMGB2 antibody; HMGB2_ antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens ()
UniProt ID:P26583
Immunogen:Recombinant High mobility group protein B2 protein (43-185AA)
Raised in:Rabbit
Reactivity:
Tested Applications:ELISA
Background:MµLtifunctional protein with various roles in different cellµLar compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regµLatory sequences into close proximity (PubMed:7797075, PubMed:11909973, PubMed:19522541, PubMed:18413230, PubMed:19965638, PubMed:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimµLating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellµLar compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimµLus coupled with proinflammatory activity (By similarity). Involved in modµLation of neurogenesis probably by regµLation of neural stem proliferation (By similarity). Involved in articµLar cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity).
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjµgate:HRP
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:HMGB2
Research Areas:Epigenetics and Nuclear Signaling