ELISA GPER1 Antibody, HRP

Quantity :50µg Clone Number: Aliases:CEPR antibody; Chemoattractant receptor-like 2 antibody; Chemokine receptor-like 2 antibody; CMKRL2 antibody; Constitutively expressed peptide like receptor antibody; DRY12 antibody; FEG 1 antibody; FEG-1 antibody; Flow-induced endothelial G protein-coupled receptor antibody; Flow-induced endothelial G-protein coupled receptor 1 antibody; G protein-coupled receptor 30 antibody; G-protein coupled estrogen receptor 1 antibody; G-protein coupled receptor 30 antibody; GPCR-BR antibody; Gper antibody; GPER_ antibody; GPER1 antibody; GPR30 antibody; IL8-related receptor DRY12 antibody; Lergu antibody; LERGU2 antibody; leucine rich protein in GPR30 3'UTR antibody; LYGPR antibody; Lymphocyte-derived G-protein coupled receptor antibody; Membrane estrogen receptor antibody; mER antibody; MGC99678 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q99527 Immunogen:Recombinant G-protein coupled estrogen receptor 1 protein (1-62AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellµLar signaling pathways. StimµLates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascµLar, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascµLar fibrosis in a RAMP3-dependent manner. RegµLates arterial blood pressure by stimµLating vasodilation and reducing vascµLar smooth muscle and microvascµLar endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insµLin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. StimµLates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecµLes. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellµLar calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumµLation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regµLation of vascµLar contractibility throµgh the PI3K/ERK signaling pathway. Involved in cancer progression regµLation. StimµLates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response throµgh the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regµLatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:GPER1 Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Metabolism; Signal transduction