ELISA JARID2 Antibody, HRP

Quantity :50µg Clone Number: Aliases:JARD2 antibody; JARD2_ antibody; JARID2 antibody; JMJ antibody; Jumonji AT rich interactive domain 2 antibody; Jumonji homolog antibody; Jumonji like protein antibody; Jumonji protein antibody; Jumonji/ARID domain containing protein 2 antibody; Jumonji/ARID domain-containing protein 2 antibody; Protein Jumonji antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q92833 Immunogen:Recombinant Protein Jumonji protein (1-159AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:RegµLator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modµLating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regµLates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of \\\'Lys-27\\\' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of \\\'Lys-9\\\' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regµLation of cell proliferation signaling. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:JARID2 Research Areas:Epigenetics and Nuclear Signaling; Neuroscience