ELISA ACD Antibody, Biotin

Quantity :50µg Clone Number: Aliases:Acd antibody; ACD_ antibody; Adrenocortical dysplasia homolog antibody; Adrenocortical dysplasia protein homolog antibody; PIP1 antibody; POT1 and TIN2 organizing protein antibody; POT1 and TIN2-interacting protein antibody; TIN2 interacting protein 1 antibody; TINT1 antibody; TPP1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96AP0 Immunogen:Recombinant Adrenocortical dysplasia protein homolog protein (328-497AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Component of the shelterin complex (telosome) that is involved in the regµLation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. ModµLates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ACD Research Areas:Epigenetics and Nuclear Signaling; Cell biology