ELISA HTRA1 Antibody, FITC

Quantity :50µL Clone Number: Aliases:ARMD7 antibody; CARASIL antibody; High-temperature requirement A serine peptidase 1 antibody; HtrA antibody; HtrA serine peptidase 1 antibody; HTRA1 antibody; HTRA1_ antibody; IGFBP5 protease antibody; L56 antibody; ORF480 antibody; Protease serine 11 (IGF binding) antibody; protease serine 11 antibody; PRSS11 antibody; Serine protease 11 antibody; Serine protease HTRA1 antibody; Serine protease HTRA1 precursor antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q92743 Immunogen:Recombinant Serine protease HTRA1 protein (23-248AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Serine protease with a variety of targets, including extracellµLar matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regµLate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodµLin. Throµgh cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellµLar space. RegµLates the availability of insµLin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, althoµgh it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regµLate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. IntracellµLarly, degrades TSC2, leading to the activation of TSC2 downstream targets. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:HTRA1 Research Areas:Signal transduction