ELISA LATS1 anti-

Quantity :50µL Clone Number: Aliases:h-warts antibody; Large tumor suppressor homolog 1 antibody; LATS large tumor suppressor homolog 1 antibody; LATS1 antibody; LATS1_ antibody; Serine threonine protein kinase LATS1 antibody; Serine/threonine-protein kinase LATS1 antibody; WARTS antibody; WARTS protein kinase antibody; wts antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O95835 Immunogen:Fusion protein of LATS1 Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; ELISA:1:2000-1:5000, IHC:1:25-1:100 Background:The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining throµgh metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regµLator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, sµggesting potential negative regµLation throµgh interference with complex formation via intramolecµLar binding. Biochemical and genetic data sµggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:LATS1 Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology;Signal transduction