ELISA LDLRAP1 anti-

Quantity :50µL Clone Number: Aliases:ARH antibody; ARH GENE antibody; ARH_ antibody; ARH1 antibody; ARH2 antibody; Autosomal recessive hypercholesterolemia protein antibody; DKFZp586D0624 antibody; FHCB1 antibody; FHCB2 antibody; LDL receptor adaptor protein antibody; Ldlrap1 antibody; Low density lipoprotein receptor adapter protein 1 antibody; MGC34705 antibody; OTTHUMP00000008526 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q5SW96 Immunogen:Recombinant Low density lipoprotein receptor adapter protein 1 protein (59-308AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regµLate clathrin bud assembly at the cell surface. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:LDLRAP1 Research Areas:CardiovascµLar; Metabolism; Signal transduction