ELISA HIC1 anti-
Quantity :50µg
Clone Number:
Aliases:Hic 1 antibody; HIC ZBTB transcriptional repressor 1 antibody; Hic-1 antibody; Hic1 antibody; HIC1_ antibody; Hypermethylated in cancer 1 antibody; Hypermethylated in cancer 1 protein antibody; ZBTB29 antibody; Zinc finger and BTB domain-containing protein 29 antibody; ZNF901 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens ()
UniProt ID:Q14526
Immunogen:Recombinant Hypermethylated in cancer 1 protein (297-418AA)
Raised in:Rabbit
Reactivity:
Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:200-1:500
Background:Transcriptional repressor. Recognizes and binds to the consensus sequence \\\'5-[CG]NG[CG]GGGCA[CA]CC-3\\\'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regµLation of SIRT1 and thereby is involved in regµLation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regµLation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regµLation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjµgate:Non-conjµgated
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:HIC1
Research Areas:Epigenetics and Nuclear Signaling; Cancer