ELISA KISS1 anti-

Quantity :50µg Clone Number: Aliases:KISS 1 antibody; KiSS 1 metastasis suppressor antibody; Kiss1 antibody; KISS1_ antibody; Kisspeptin 1 antibody; Kisspeptin 10 antibody; Kisspeptin 13 antibody; Kisspeptin 14 antibody; Kisspeptin antibody; Kisspeptin-1 antibody; Kisspeptin-10 antibody; Kisspeptin-54 antibody; Kisspeptin1 antibody; Malignant melanoma metastasis suppressor antibody; Metastasis suppressor KiSS 1 antibody; Metastasis suppressor KiSS1 antibody; Metastin antibody; MGC39258 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q15726 Immunogen:Recombinant Metastasis-suppressor KiSS-1 protein (20-138AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regµLate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellµLar Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regµLator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regµLation of the gonadotropic axis at puberty and in adµLthood. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:KISS1 Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Cancer; Cell biology