ELISA KCNC3 anti-

Quantity :50µg Clone Number: Aliases:Kcnc3 antibody; KCNC3_ antibody; KSHIIID antibody; KV3.3 antibody; Potassium voltage gated channel Shaw related subfamily member 3 antibody; Potassium voltage gated channel subfamily C member 3 antibody; Potassium voltage-gated channel subfamily C member 3 antibody; SCA13 antibody; Shaw related subfamily, member 3 antibody; Shaw related voltage gated potassium channel protein 3 antibody; Spinocerebellar ataxia 13 antibody; Voltage gated potassium channel protein KV3.3 antibody; Voltage gated potassium channel subunit Kv3.3 antibody; Voltage-gated potassium channel subunit Kv3.3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q14003 Immunogen:Recombinant Potassium voltage-gated channel subfamily C member 3 protein (638-745AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200 Background:Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel throµgh which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed:10712820, PubMed:26997484, PubMed:22289912, PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792). It plays a role in the regµLation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regµLating the duration and frequency of action potentials that in turn regµLate the activity of voltage-gated Ca(2+) channels and cellµLar Ca(2+) homeostasis (By similarity). Required for normal motor function (PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed:26997484). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:KCNC3 Research Areas:Neuroscience