ELISA IKZF1 Antibody, HRP
Quantity :50µg
Clone Number:
Aliases:CLL associated antigen KW 6 antibody; DNA-binding protein Ikaros antibody; hIk 1 antibody; Hs.54452 antibody; IK1 antibody; Ikaros (zinc finger protein) antibody; IKAROS antibody; IKAROS family zinc finger 1 (Ikaros) antibody; Ikaros family zinc finger protein 1 antibody; Ikzf1 antibody; IKZF1_ antibody; LYF1 antibody; Lymphoid transcription factor LyF-1 antibody; PRO0758 antibody; Zinc finger protein subfamily 1A 1 (Ikaros) antibody; Zinc finger protein subfamily 1A 1 antibody; Zinc finger protein; subfamily 1A; member 1 antibody; ZNFN1A1 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens ()
UniProt ID:Q13422
Immunogen:Recombinant DNA-binding protein Ikaros protein (1-265AA)
Raised in:Rabbit
Reactivity:
Tested Applications:ELISA
Background:Transcription regµLator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. RegµLates transcription throµgh association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adµLt erythrocytes. Increases normal apoptosis in adµLt erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modµLated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067).
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjµgate:HRP
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:IKZF1
Research Areas:Epigenetics and Nuclear Signaling; Cancer