ELISA GPS1 anti-

Quantity :50µL Clone Number: Aliases:COP9 signalosome complex subunit 1 antibody; COP9 signalosome subunit 1 antibody; COPS1 antibody; CSN 1 antibody; CSN1_ antibody; FUS6/COP11; Arabidopsis; homolog of antibody; G protein pathway suppressor 1 antibody; GPS-1 antibody; Gps1 antibody; JAB1-containing signalosome subunit 1 antibody; Protein GPS1 antibody; Protein MFH antibody; SGN1 antibody; Signalosome subunit 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13098 Immunogen:Recombinant COP9 signalosome complex subunit 1 protein (222-491AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200 Background:Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellµLar and developmental processes. The CSN complex is an essential regµLator of the ubiquitin (Ubl) conjµgation pathway by mediating the deneddylation of the cµLlin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:GPS1 Research Areas:Neuroscience; Cell biology; Signal transduction