ELISA HINT1 anti-
Quantity :100µL
Clone Number:
Aliases:Adenosine 5' monophosphoramidase antibody; Adenosine 5''-monophosphoramidase antibody; HINT 1 antibody; HINT1 antibody; HINT1_ antibody; Histidine triad nucleotide binding protein 1 antibody; Histidine triad nucleotide-binding protein 1 antibody; PKCI 1 antibody; PKCI-1 antibody; PKCI1 antibody; PRKCNH1 antibody; Protein kinase C inhibitor 1 antibody; Protein kinase C interacting protein 1 antibody; Protein kinase C-interacting protein 1 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens ()
UniProt ID:P49773
Immunogen:SyntheQuantityd peptide derived from internal of HINT1.
Raised in:Rabbit
Reactivity:, Mouse, Rat
Tested Applications:ELISA, WB, IF; WB:1:500-1:3000, IF:1:100-1:500
Background:Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sµLfide. In addition, functions as scaffolding protein that modµLates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. ModµLates p53/TP53 levels and p53/TP53-mediated apoptosis. ModµLates proteasomal degradation of target proteins by the SCF (SKP2-CµL1-F-box protein) E3 ubiquitin-protein ligase complex.
Brzoska P.M., Genomics 36:151-156(1996).
Brzoska P.M., Proc. Natl. Acad. Sci. U.S.A. 92:7824-7828(1995).
Ota T., Nat. Genet. 36:40-45(2004).
Clonality:Polyclonal
Isotype:IgG
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Conjµgate:Non-conjµgated
Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form:liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:HINT1
Research Areas:Epigenetics and Nuclear Signaling;Cancer