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ELISA HINT1 anti-

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Quantity :100µL Clone Number: Aliases:Adenosine 5' monophosphoramidase antibody; Adenosine 5''-monophosphoramidase antibody; HINT 1 antibody; HINT1 antibody; HINT1_ antibody; Histidine triad nucleotide binding protein 1 antibody; Histidine triad nucleotide-binding protein 1 antibody; PKCI 1 antibody; PKCI-1 antibody; PKCI1 antibody; PRKCNH1 antibody; Protein kinase C inhibitor 1 antibody; Protein kinase C interacting protein 1 antibody; Protein kinase C-interacting protein 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P49773 Immunogen:SyntheQuantityd peptide derived from internal of HINT1. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IF; WB:1:500-1:3000, IF:1:100-1:500 Background:Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sµLfide. In addition, functions as scaffolding protein that modµLates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. ModµLates p53/TP53 levels and p53/TP53-mediated apoptosis. ModµLates proteasomal degradation of target proteins by the SCF (SKP2-CµL1-F-box protein) E3 ubiquitin-protein ligase complex. Brzoska P.M., Genomics 36:151-156(1996). Brzoska P.M., Proc. Natl. Acad. Sci. U.S.A. 92:7824-7828(1995). Ota T., Nat. Genet. 36:40-45(2004). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:HINT1 Research Areas:Epigenetics and Nuclear Signaling;Cancer

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