ELISA AXIN1 Antibody, FITC

Quantity :50µg Clone Number: Aliases:AI316800 antibody; AXIN antibody; Axin 1 antibody; Axin-1 antibody; axin1 antibody; AXIN1_ antibody; Axis inhibition protein 1 antibody; Axis Inhibitor 1 antibody; Fu antibody; fused antibody; Fused; mouse; homolog of antibody; hAxin antibody; Kb antibody; Ki antibody; kinky antibody; knobbly antibody; MGC132911 antibody; MGC52315 antibody; PPP1R49 antibody; Protein Fused antibody; Protein phosphatase 1 regµLatory subunit 49 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O15169 Immunogen:Recombinant Axin-1 protein (418-707AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Component of the beta-catenin destruction complex required for regµLating CTNNB1 levels throµgh phosphorylation and ubiquitination, and modµLating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regµLates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon µLtraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:AXIN1 Research Areas:Cell biology; Tags & Cell Markers; Signal transduction; Stem cells