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ELISA IGHM Antibody, HRP

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Quantity :50µg Clone Number: Aliases:IGHMImmunoglobµLin heavy constant mu antibody; Ig mu chain C region antibody; Ig mu chain C region BOT antibody; Ig mu chain C region GAL antibody; Ig mu chain C region OU antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P01871 Immunogen:Recombinant ImmunoglobµLin heavy constant mu protein (45-178AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Constant region of immunoglobµLin heavy chains. ImmunoglobµLins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobµLins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobµLins-secreting plasma cells. Secreted immunoglobµLins mediate the effector phase of humoral immunity, which resµLts in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobµLin has two antigen binding sites with remarkable affinity for a particµLar antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particµLar antigen (PubMed:17576170, PubMed:20176268). IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellµLar waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobµLins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts (PubMed:3137579, PubMed:16895553). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:IGHM Research Areas:Immunology

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