ELISA AXL Antibody, FITC

Quantity :50µg Clone Number: Aliases:Adhesion related kinase antibody; AI323647 antibody; Ark antibody; Axl antibody; AXL oncogene antibody; AXL receptor tyrosine kinase antibody; AXL transforming gene antibody; AXL transforming sequence/gene antibody; EC 2.7.10.1 antibody; JTK11 antibody; Oncogene AXL antibody; Tyro7 antibody; Tyrosine protein kinase receptor UFO antibody; Tyrosine-protein kinase receptor UFO antibody; UFO antibody; UFO_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P30530 Immunogen:Recombinant Tyrosine-protein kinase receptor UFO protein (312-447AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Receptor tyrosine kinase that transduces signals from the extracellµLar matrix into the cytoplasm by binding growth factor GAS6 and which is thus regµLating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regµLatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regµLation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:AXL Research Areas:Cancer; Cell biology; Tags & Cell Markers; Signal transduction