ELISA HLA-E anti-

Quantity :50µg Clone Number: Aliases:HLA-E antibody; HLA-6.2 antibody; HLAEHLA class I histocompatibility antigen antibody; alpha chain E antibody; MHC class I antigen E) [Cleaved into: Soluble HLA class I histocompatibility antigen antibody; alpha chain E antibody; sHLA-E)] antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P13747 Immunogen:Recombinant HLA class I histocompatibility antigen, alpha chain E protein (33-261AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Non-classical major histocompatibility class Ib molecµLe involved in immune self-nonself discrimination. In complex with B2M/beta-2-microglobµLin binds nonamer self-peptides derived from the signal sequence of classical MHC class Ia molecµLes (VL9 peptides) (PubMed:9754572, PubMed:18083576, PubMed:18339401). Peptide-bound HLA-E-B2M heterotrimeric complex primarily functions as a ligand for natural killer (NK) cell inhibitory receptor KLRD1-KLRC1, enabling NK cells to monitor the expression of other MHC class I molecµLes in healthy cells and to tolerate self (PubMed:9754572, PubMed:9486650, PubMed:17179229, PubMed:18083576). Upon cellµLar stress, preferentially binds signal sequence-derived peptides from stress-induced chaperones and is no longer recognized by NK cell inhibitory receptor KLRD1-KLRC1, resµLting in impaired protection from NK cells (PubMed:12461076). Binds signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecµLes and acts as a ligand for NK cell activating receptor KLRD1-KLRC2, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy (PubMed:9754572, PubMed:30134159). Besides self-peptides, can also bind and present pathogen-derived peptides conformationally similar to VL9 peptides to alpha-beta T cell receptor (TCR) on unconventional CD8+ cytotoxic T cells, µLtimately triggering antimicrobial immune response (PubMed:16474394, PubMed:30087334). Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:HLA-E Research Areas:Immunology