ELISA AKT1 (Ab-308) anti-

Quantity :100µL Clone Number: Aliases:AKT 1 antibody; AKT antibody; AKT1 antibody; AKT1_ antibody; C AKT antibody; cAKT antibody; MGC99656 antibody; PKB alpha antibody; PKB antibody; PKB-ALPHA antibody; PRKBA antibody; Protein Kinase B Alpha antibody; Protein kinase B antibody; Proto-oncogene c-Akt antibody; RAC Alpha antibody; RAC antibody; Rac protein kinase alpha antibody; RAC Serine/Threonine Protein Kinase antibody; RAC-alpha serine/threonine-protein kinase antibody; RAC-PK-alpha antibody; v akt murine thymoma viral oncogene homolog 1 antibody; vAKT Murine Thymoma Viral Oncogene Homolog 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P31749 Immunogen:Peptide sequence around aa.306~310 (M-K-T-F-C) derived from AKT1. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; WB:1:500-1:1000, IHC:1:50-1:200 Background: General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insµLin and insµLin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insµLin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insµLin-stimµLated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insµLin-induced activation of glycogen synthase. Tremblay F, et al. (2005) Diabetes; 54(9): 2674-84. Xu BE, et al. (2005) J Biol Chem; 280(40): 34218-23. Samuels Y, et al. (2005) Cancer Cell; 7(6): 561-73. Di Maira G, et al. (2005) Cell Death Differ; 12(6): 668-77. Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:AKT1 Research Areas:Epigenetics and Nuclear Signaling?Neuroscience?Cancer;Metabolism;Signal transduction