ELISA HMGCS1 anti-

Quantity :50µL Clone Number: Aliases:3 hydroxy 3 methylglutaryl Coenzyme A synthase 1 (soluble) antibody; 3-hydroxy-3-methylglutaryl coenzyme A synthase antibody; cytoplasmic antibody; EC 2.3.3.10 antibody; HMCS1_ antibody; HMG CoA synthase antibody; HMG-CoA synthase antibody; HMGCS antibody; HMGCS1 antibody; Hydroxymethylglutaryl CoA synthase, cytoplasmic antibody; Hydroxymethylglutaryl-CoA synthase antibody; MGC90332 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q01581 Immunogen:Synthetic peptide of HMGCS1 Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 Background:HMG-CoA Synthase exists as both a mitochondrial (mHMGCS) and cytoplasmic (cHMGCS) enzyme that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The HMG-CoA produced by cHMGCS is transformed into mevalonate by HMG-CoA reductase, which starts isoprenoid biosynthesis. End products of the isoprenoid pathway include cholesterol, ubiquinone, dolichol, isopentenyl adenosine and farnesyl groups. mHMGCS, together with HMG-CoA Lyase, is responsible for ketone body biosynthesis. mHMGCS is expressed in liver and kidney. Fasting, cAMP and fatty acids increase the level of transcription of mHMGCS, while feeding and insµLin repress it. A regµLatory element within the mHMGCS promoter confers transcriptional regµLation by PPAR, RXR, COUP-TF and HNF-4. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:HMGCS1 Research Areas:Others