ELISA IRS1 (Ab-636) anti-

Quantity :100µL Clone Number: Aliases:HIRS 1 antibody; HIRS1 antibody; InsµLin receptor substrate 1 antibody; IRS 1 antibody; IRS-1 antibody; IRS1 antibody; IRS1_ antibody; OTTHUMP00000164234 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P35568 Immunogen:Peptide sequence around aa.634~638 (P-M-S-P-K) derived from IRS-1. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200 Background:May mediate the control of various cellµLar processes by insµLin. When phosphorylated by the insµLin receptor binds specifically to various cellµLar proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regµLatory p85 subunit Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98(8): 4640-4645 Tzatsos A, et al. (2006) Mol Cell Biol; 26(1): 63-76 Kadowaki T, et al. (2000) J Clin Invest; 106(4): 459-465 Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98(8): 4640-4645 Szanto I, et al. (2000) Proc Natl Acad Sci U S A; 97(5): 2355-2360 Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:IRS1 Research Areas:Neuroscience?Cancer?CardiovascµLar;Tags & Cell Markers;Metabolism;Signal transduction