ELISA GSK3A|GSK3B (Ab-279|216) anti-

Quantity :100µL Clone Number: Aliases:Factor A; GSK-3 alpha/beta; kinase GSK3-alpha/beta Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P49840/P49841 Immunogen:Peptide sequence around aa.277~281/214~218 (V-S-Y-I-C) derived from GSK3?/? Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB; WB:1:500-1:1000 Background:Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regµLatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Chin PC, et al. Brain Res Mol Brain Res 2005 Jun 13; 137(1-2): 193-201 Takahashi-Yanaga F, et al. Biochem Biophys Res Commun 2004 Apr 02; 316(2): 411-415 Fan G, et al. J Biol Chem 2003 Dec 26; 278(52): 52432-52436 Liao X, et al. Mol Cancer Ther 2003 Nov; 2(11): 1215-1222 Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:GSK3A/GSK3B Research Areas:CardiovascµLar?Cell biology;Signal transduction?Stem cells