ELISA KLHL20 anti-

Quantity :50µg Clone Number: Aliases:Kelch like ECT2 interacting protein antibody; Kelch like protein 20 antibody; Kelch like protein X antibody; Kelch motif containing protein antibody; Kelch-like ECT2-interacting protein antibody; Kelch-like protein 20 antibody; Kelch-like protein X antibody; KHLHX antibody; KLEIP antibody; KLH20_ antibody; KLHL20 antibody; KLHLX antibody; RP3-383J4.3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9Y2M5 Immunogen:Recombinant Kelch-like protein 20 protein (1-200AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200 Background:Substrate-specific adapter of a BCR (BTB-CµL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regµLator of apoptosis (PubMed:20389280). The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates \\\'Lys-33\\\'-linked ubiquitination (PubMed:24768539). Involved in anterograde Golgi to endosome transport by mediating \\\'Lys-33\\\'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking (PubMed:24768539). Also acts as a regµLator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regµLator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (PubMed:21670212). In case of tumor, the BCR(KLHL20) E3 ubiquitin ligase complex is involved in tumor hypoxia: following hypoxia, the BCR(KLHL20)complex mediates ubiquitination and degradation of PmL, potentiating HIF-1 signaling and cancer progression (PubMed:21840486). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:KLHL20 Research Areas:CardiovascµLar; Metabolism; Signal transduction