ELISA HMGB1 anti-

Quantity :50µL Clone Number: Aliases:Amphoterin antibody; Chromosomal protein; nonhistone; HMG1 antibody; DKFZp686A04236 antibody; High mobility group 1 antibody; High mobility group box 1 antibody; High mobility group protein 1 antibody; High mobility group protein B1 antibody; high-mobility group (nonhistone chromosomal) protein 1 antibody; HMG-1 antibody; HMG1 antibody; HMG3 antibody; HMGB 1 antibody; HMGB1 antibody; HMGB1_ antibody; NONHISTONE CHROMOSOMAL PROTEIN HMG1 antibody; SBP 1 antibody; SµLfoglucuronyl carbohydrate binding protein antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P09429 Immunogen:Synthetic peptide of HMGB1 Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 Background:High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence sµggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NF B family, ATF-2 and c-Jun to activate transcription. Other studies indicate that phosphorylation of HMG protein is required to stimµLate the transcriptional activity of the protein. HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:HMGB1 Research Areas:Epigenetics and Nuclear Signaling