ELISA GRK6 anti-

Quantity :100µL Clone Number: Aliases:FLJ32135 antibody; G protein coupled receptor kinase 6 antibody; G protein coupled receptor kinase GRK6 antibody; G protein-coupled receptor kinase 6 antibody; G protein-coupled receptor kinase GRK6 antibody; Gprk6 antibody; Grk6 antibody; GRK6_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P43250 Immunogen:SyntheQuantityd peptide derived from N-terminal of GRK6. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IF; WB:1:500-1:3000, IF:1:100-1:500 Background:Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis By similarity. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). Benovic J.L., J. Biol. Chem. 268:19521-19527(1993). Haribabu B., Proc. Natl. Acad. Sci. U.S.A. 90:9398-9402(1993). Stoffel R.H., J. Biol. Chem. 269:27791-27794(1994). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:GRK6 Research Areas:CardiovascµLar;Signal transduction