ELISA ARID1B anti-

Quantity :100µL Clone Number: Aliases:ARID1B antibody; BAF250B antibody; DAN15 antibody; KIAA1235 antibody; OSA2AT-rich interactive domain-containing protein 1B antibody; ARID domain-containing protein 1B antibody; BRG1-associated factor 250b antibody; BAF250B antibody; BRG1-binding protein hELD/OSA1 antibody; Osa homolog 2 antibody; hOsa2 antibody; p250R antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8NFD5 Immunogen:SyntheQuantityd peptide derived from interal of BAF250B. Raised in:Rabbit Reactivity:, Rat Tested Applications:ELISA, WB, IF; WB:1:500-1:3000, IF:1:100-1:500 Background:Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adµLt state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the mµLtipotent neural stem cells. The nBAF complex along with CREST plays a role regµLating the activity of genes essential for dendrite growth By similarity. Binds DNA non-specifically. Mungall A.J., Nature 425:805-811(2003). Mangel L., J. Biol. Chem. 273:30466-30471(1998). Imbert G., Nat. Genet. 14:285-291(1996). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ARID1B Research Areas:Epigenetics and Nuclear Signaling