ELISA GRIN2B (Ab-1303) anti-

Quantity :100µL Clone Number: Aliases:AW490526 antibody; EIEE27 antibody; Glutamate [NMDA] receptor subunit epsilon 2 antibody; Glutamate [NMDA] receptor subunit epsilon-2 antibody; Glutamate Receptor Ionotropic N Methyl D Aspartate 2B antibody; Glutamate Receptor Ionotropic N Methyl D Aspartate subunit 2B antibody; Glutamate receptor ionotropic NMDA2B antibody; Glutamate receptor subunit epsilon 2 antibody; Glutamate receptor, ionotropic, NMDA2B (epsilon 2) antibody; GRIN 2B antibody; GRIN2B antibody; hNR 3 antibody; hNR3 antibody; MGC142178 antibody; MGC142180 antibody; MRD6 antibody; N methyl D asparate receptor channel subunit epsilon 2 antibody; N methyl D aspartate receptor subtype 2B antibody; N methyl D aspartate receptor subunit 2B antibody; N methyl D aspartate receptor subunit 3 antibody; N-methyl D-aspartate receptor subtype 2B antibody; N-methyl-D-aspartate receptor subunit 3 antibody; NMDA NR2B antibody; NMDA R2B antibody; NMDAR2B antibody; NMDE2 antibody; NMDE2_ antibody; NME2 antibody; NR2B antibody; NR3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13224 Immunogen:SyntheQuantityd non-phosphopeptide derived from GRIN2B around the phosphorylation site of serine 1303 (Q-H-S(p)-Y-D). Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx throµgh them, resµLting in an irreversible neuronal death By similarity. Lasky L.A., J. Biol. Chem. 275:21477-21485(2000). Mandich P., Neurosci. Lett. 239:49-53(1997). Ajmar F., Genomics 22:216-218(1994). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:GRIN2B Research Areas:Neuroscience