ELISA AGER anti-

Quantity :50µg Clone Number: Aliases:Advanced glycosylation end product-specific receptor antibody; Ager antibody; DAMA 358M23.4 antibody; MGC2235 antibody; MGC22357 antibody; RAGE_ antibody; Receptor for advanced glycation end products antibody; Receptor for advanced glycosylation end products antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q15109 Immunogen:Recombinant Advanced glycosylation end product-specific receptor protein (23-342AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500 Background:Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumµLate in vascµLar tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascµLar inflammation in conditions such as atherosclerosis and in particµLar as a complication of diabetes. AGE/RAGE signaling plays an important role in regµLating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellµLar activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling By similarity. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellµLar to the intracellµLar space in cortical neurons. ABPP-initiated RAGE signaling, especially stimµLation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:AGER Research Areas:Neuroscience; CardiovascµLar