ELISA JAK3 (Ab-785) anti-

Quantity :100µL Clone Number: Aliases:EC 2.7.10.2 antibody; JAK 3 antibody; JAK L antibody; JAK-3 antibody; Jak3 antibody; JAK3 antibody; JAK3_ antibody; JAKL antibody; Janus kinase 3 (a protein tyrosine kinase; leukocyte) antibody; Janus kinase 3 antibody; Janus Kinase3 antibody; L JAK antibody; L-JAK antibody; Leukocyte janus kinase antibody; LJAK antibody; Protein tyrosine kinase leukocyte antibody; Tyrosine protein kinase JAK3 antibody; Tyrosine-protein kinase JAK3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P52333 Immunogen:SyntheQuantityd non-phosphopeptide derived from JAK3 around the phosphorylation site of tyrosine 785 (S-D-Y(p)-E-L). Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100 Background:Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecµLes bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion. Kawamura M., Proc. Natl. Acad. Sci. U.S.A. 91:6374-6378(1994). Lai K.S., J. Biol. Chem. 270:25028-25036(1995). Grimwood J., Nature 428:529-535(2004). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:JAK3 Research Areas:Epigenetics and Nuclear Signaling;Cancer;Signal transduction