ELISA KDM4D anti-

Quantity :50µL Clone Number: Aliases:JHD3D antibody; JHDM3D antibody; JmjC domain-containing histone demethylation protein 3D antibody; Jumonji domain-containing protein 2D antibody; Kdm4d antibody; KDM4D_ antibody; Lysine-specific demethylase 4D antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q6B0I6 Immunogen:Fusion protein of KDM4D Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, IHC; ELISA:1:1000-1:2000, IHC:1:25-1:100 Background:JMJD2D (Jumonji domain-containing protein 2D), also known as JHDM3D or KDM4D, is a 520 amino acid protein that belongs to the JHDM3 histone demethylase family. Localized to the nucleus, JMJD2D functions as a histone demethylase that removes specific methyl residues from Histone H3, thereby playing a crucial role in the histone code. JMJD2D binds iron as a cofactor and contains one JMJC domain and one JMJN domain, both of which are thoµght to exhibit enzymatic activity during chromatin remodeling events. In addition, JMJD2D forms a complex with the ligand-bound form of the androgen receptor (AR) and, throµgh this interaction, activates AR expression. Overexpression of AR is associated with prostate cancer, sµggesting that, via its ability to upregµLate AR, JMJD2D may be involved in carcinogenesis. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:KDM4D Research Areas:Epigenetics and Nuclear Signaling