ELISA LEPR anti-

Quantity :50µg Clone Number: Aliases:CD 295 antibody; CD295 antibody; CD295 antigen antibody; Db antibody; Fa antibody; HuB219 antibody; LEP R antibody; LEP-R antibody; LEPR antibody; LEPR_ antibody; LEPRD antibody; Leptin receptor antibody; Leptin receptor fatty antibody; Leptin receptor gene related protein antibody; Leptin receptor precursor antibody; Leptin receptor precursor antibody; OB R gene related protein antibody; OB receptor antibody; OB-R antibody; OB-RGRP antibody; obl antibody; Obr antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P48357 Immunogen:Recombinant Leptin receptor protein (874-1075AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IF; Recommended dilution: IF:1:50-1:200 Background:Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects throµgh the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regµLating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regµLates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regµLates pancreatic beta-cell function and insµLin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25060689, PubMed:12504075, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimµLation of POMC and fµLl repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regµLate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regµLation of counter-regµLatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regµLating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:LEPR Research Areas:Cancer; CardiovascµLar; Metabolism; Signal transduction