ELISA ANGPT1 anti-

Quantity :50µg Clone Number: Aliases:AGP 1 antibody; AGP1 antibody; AGPT antibody; ANG 1 antibody; ANG antibody; ANG-1 antibody; ANG1 antibody; Angiopoietin-1 antibody; Angiopoietin1 antibody; ANGP1_ antibody; ANGPT 1 antibody; Angpt1 antibody; KIAA0003 antibody; OTTHUMP00000227592 antibody; OTTHUMP00000227599 antibody; OTTHUMP00000227600 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q15389 Immunogen:Recombinant Angiopoietin-1 protein (16-498AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200 Background:Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regµLation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascµLar quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascµLar stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecµLes from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellµLar matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and µLtimately to the stimµLation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ANGPT1 Research Areas:Cancer; CardiovascµLar; Metabolism