ELISA HSPA5 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:78 kDa glucose regµLated protein antibody; 78 kDa glucose-regµLated protein antibody; AL022860 antibody; AU019543 antibody; BIP antibody; D2Wsu141e antibody; D2Wsu17e antibody; Endoplasmic reticµLum lumenal Ca(2+)-binding protein grp78 antibody; Endoplasmic reticµLum lumenal Ca2+ binding protein grp78 antibody; Epididymis secretory sperm binding protein Li 89n antibody; FLJ26106 antibody; Glucose RegµLated Protein 78 antibody; Glucose RegµLated Protein 78kDa antibody; GRP 78 antibody; GRP-78 antibody; GRP78 antibody; GRP78_ antibody; Heat shock 70 kDa protein 5 antibody; Heat Shock 70kDa Protein 5 antibody; Heat shock protein family A (Hsp70) member 5 antibody; HEL S 89n antibody; Hsce70 antibody; HSPA 5 antibody; HSPA5 antibody; ImmunoglobµLin Heavy Chain Binding Protein antibody; ImmunoglobµLin heavy chain-binding protein antibody; mBiP antibody; MIF2 antibody; Sez7 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P11021 Immunogen:Recombinant Endoplasmic reticµLum chaperone BiP protein (25-293AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Endoplasmic reticµLum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticµLum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:1550958, PubMed:19538957). In the unstressed endoplasmic reticµLum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). AccumµLation of misfolded protein in the endoplasmic reticµLum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticµLum (ER). May function as an allosteric modµLator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regµLate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:HSPA5 Research Areas:Tags & Cell Markers