ELISA IRAK1BP1 anti-

Quantity :50µL Clone Number: Aliases:ActA binding protein 3 antibody; AIP70 antibody; IKBP1_ antibody; Interleukin 1 receptor associated kinase 1 binding protein 1 antibody; Interleukin-1 receptor-associated kinase 1-binding protein 1 antibody; IRAK1-binding protein 1 antibody; IRAK1BP1 antibody; Signaling molecµLe that associates with Pelle-like kinase antibody; SIMPL antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q5VVH5 Immunogen:Fusion protein of IRAK1BP1 Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC; ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 Background:SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fµLly active. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:IRAK1BP1 Research Areas:Immunology;Signal transduction