ELISA ABL1 Antibody, FITC

Quantity :50µg Clone Number: Aliases:Abelson murine leukemia viral oncogene homolog 1 antibody; Abelson tyrosine protein kinase 1 antibody; Abl 1 antibody; ABL antibody; ABL proto oncogene 1 non receptor tyrosine kinase antibody; ABL1 antibody; ABL1_ antibody; bcr/abl antibody; bcr/c abl oncogene protein antibody; c ABL antibody; c abl oncogene 1 non receptor tyrosine kinase antibody; c abl oncogene 1 receptor tyrosine kinase antibody; c ABL1 antibody; JTK7 antibody; p150 antibody; Proto oncogene tyrosine protein kinase ABL1 antibody; Proto-oncogene c-Abl antibody; Tyrosine-protein kinase ABL1 antibody; v abl Abelson murine leukemia viral oncogene homolog 1 antibody; v abl antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P00519 Immunogen:Recombinant Tyrosine-protein kinase ABL1 protein (4-194AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellµLar stimµLi, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling throµgh tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubµLe-binding proteins). Phosphorylation of WASF3 is critical for the stimµLation of lamellipodia formation and cell migration. Involved in the regµLation of cell adhesion and motility throµgh phosphorylation of key regµLators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates mµLtiple receptor tyrosine kinases and more particµLarly promotes endocytosis of EGFR, facilitates the formation of neuromuscµLar synapses throµgh MUSK, inhibits PDGFRB-mediated chemotaxis and modµLates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regµLation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regµLates the CBL family of ubiquitin ligases that drive receptor down-regµLation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regµLating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at \\\'Tyr-717\\\' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regµLator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on \\\'Tyr-153\\\' and regµLates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regµLator of mµLtiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for mµLtiple purposes, like facilitating intracellµLar movement and host cell exit. Finally, functions as its own regµLator throµgh autocatalytic activity as well as throµgh phosphorylation of its inhibitor, ABI1. RegµLates T-cell differentiation in a TBX21-dependent manner. Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ABL1 Research Areas:Epigenetics and Nuclear Signaling; Cancer; Signal transduction